1. Successful Republican or Independent challenge from a strong political outsider.
2. Emergence of a compelling primary challenger from the Democratic Party.
3. Heightened divisions in the party over policy issues such as immigration, health care and climate change.
4. Further flare-ups of unrest and social tension over issues such as police reform, education, housing and inequality.
5. Growing Republican focus on attacking Biden’s signature “middle class-centered” economic agenda.
6. Growing resistance to Biden’s international and foreign policy agenda, including re-engagement with Iran, the US-Mexico-Canada trade agreement and China trade tensions.
7. Increasing criticism of Biden’s approach to addressing the nation’s debt crisis.
8. Growing opposition to the new administration’s judicial nominees.
9. House Republicans attempting to repeal or weaken popular legislation passed by the current Congress.
10. Possibility of the Republican Party retaking control of Congress in 2022 and Biden having to face unified opposition.